Thomas J. Purcell

Position:      PostDoc
Phone:         (415) 476-1975
Fax:             (415) 476-1902
Email:          tom.purcell@ucsf.edu

Research Interests:
     - Myosin conformational thermodynamics using EPR spectroscopy

Selected Publications:

• Naber, N., T. J. Purcell, E. Pate and R. Cooke (2007). "Dynamics of the nucleotide pocket of myosin measured by spin-labeled nucleotides." Biophys J 92(1): 172-84.


• Purcell, T. J., H. L. Sweeney and J. A. Spudich (2005). "A force- dependent state controls the coordination of processive myosin V." Proc Natl Acad Sci U S A 102(39): 13873-8.


• Rice, S. E., T. J. Purcell and J. A. Spudich (2003). "Building and using optical traps to study properties of molecular motors." Methods Enzymol 361: 112-33.


• Purcell, T. J., C. Morris, J. A. Spudich and H. L. Sweeney (2002). "Role of the lever arm in the processive stepping of myosin V." Proc Natl Acad Sci U S A 99(22): 14159-64.


• Rock, R. S., S. E. Rice, A. L. Wells, T. J. Purcell, J. A. Spudich and H. L. Sweeney (2001). "Myosin VI is a processive motor with a large step size." Proc Natl Acad Sci U S A 98(24): 13655-9.