Introduction

ARP/wARP  is a package for automated protein model building and structure refinement. It is based on a unified approach to the structure solution process by combining electron density interpretation using the concept of the hybrid model, pattern recognition in an electron density map and maximum likelihood model parameter refinement.

The ARP/wARP suite is under continuous development. The present release, Version 6.0, can be used in the following ways:

1. Automatic tracing of the density map and model building. This includes the refinement of MR solutions and the improvement of MAD and M(S)IR(AS) phases via map interpretation
2. Free atoms density modification
3. Building of the solvent structure

An overview of the ARP/wARP can be found in, e.g. the International Tables for Crystallography, Volume F: Crystallogaphy of biological macromolecules, Eds. Rossmann & Arnold, 2001, 720-722 by Lamzin, Perrakis & Wilson. Applications are presented in Perrakis, Morris, Lamzin, 1999, Nature Structural Biology, 6, 458-463. Algorithmic details are given in Lamzin & Wilson Meth. Enzym. 277, 269-305, and Morris, Perrakis & Lamzin, 2002, Acta D58, 968-975. For other publications please refer to the ARP/wARP web page http://www.embl-hamburg.de/ARP or the other references given at the end of this document.