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The Macromolecular Structure Group is part of the Department of Biochemistry and Biophysics in the School of Medicine at the University of California, San Francisco.

The MSG focuses on the study of macromolecular structure, function, and interactions through the varied research tools of biochemistry and biophysics, including X-ray Crystallography and SAXS, Electron & Light Microscopy, NMR, Mass Spectrometry, and Molecular Biology.

Associated Graduate Programs
- Biomedial Sciences (BMS)
- Tetrad
- Program in Biological Sciences (PIBS)
- Biophysics (BP)
- Chemistry & Chemical Biology (CCB)
- Pharmaceutical Sciences and Pharmacogenomics (PSPG)

Affiliated Departments
- Biochemistry & Biophysics
- Pharmaceutical Chemistry
- Cellular & Molecular Pharmacology
- Pathology

Affiliated Institutes
- Howard Hughes Medical Institute (HHMI)
- Cardiovascular Research Institute (CVRI)
- California Institute for Quantitative Biosciences (QB3)
David Agard
Agard Lab
Structure at the molecular and cellular level.
Roger Cooke
Cooke Lab
Force and motion in muscles and biological motors.
James Fraser
Fraser Lab
Conformational dynamics of enzymes and assemblies.
john Gross
Gross Lab
Structure, dynamics, and the control of mRNA metabolism.
Wendell Lim
Lim Lab
Molecular mechanisms of cellular signaling and communication.
Larissa Podust
Podust Lab
Infectious disease-related enzyme inhibition mechanisms
Robert Stroud
Stroud Lab
Molecular mechanisms of certain key biological processes.
Yifan Cheng
Cheng Lab
Structures of macromolecular
assemblies by cryoEM.

Robert Fletterick
Fletterick Lab
Structure-function relationships and protein recognition.
Adam Frost
Frost Lab
Structure and Function of Cellular Machines.
Natalia Jura
Jura Lab
Molecular basis for Receptor Tyrosine Kinase signaling.
Daniel Minor
Minor Lab
Ion Channel Structure and Function.
John Sedat
Sedat Lab
Organization, architecture and the functional roles of chromosomes.
Jonathan Weissman
Weissman Lab
Studies of how efficient protein folding is achieved in vivo.
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