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We focus on  fundamental areas in mechanistic cell biology: protein homeostasis, control of microtubule cytoskeleton, the newly discovered cell biology of giant bacteriophages.

Our strategy is to use and develop a broad array of methods to tackle otherwise intractable problems in vitro, allowing us to gain unique and significant molecular insights.

Additionally we are pursuing translational studies of protein complexes critical for a broad range of human diseases. We also continue significant technological advances - the most revolutionary being our aiding the development of the game-changing single-electron counting cryoEM camera and most recently, developing greatly improved software for correcting beam-induced motion.







600 16th St, San Francisco, California, 94158-2517 | phone (415)476-2521 | fax (415) 476-1902




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