Research Focus

Our laboratory has focused on elucidating the basic principles of macromolecular and supramolecular structure and function. Using alpha-lytic protease (aLP) as a model system, we have pursued the mechanism of enzyme specificity and explored fundamental concepts of protein stability and folding. This understanding is now being applied to the problem of nuclear receptor signaling. In parallel, we have made significant progress in analyzing the structure of centrosomes and chromosomes. Throughout, we have pioneered the development of new methods for determining structures at both the molecular and cellular levels.