The Cooke Lab UCSF Mission Bay

Welcome to the Cooke Lab at UCSF!

The Cooke Lab studies the Biophysics and Physiology of muscle. We have recently explored a mechanism that plays a role in the metabolic rate of resting skeletal muscle. This involves an equilibrium between two states of the motor protein, myosin. In one state myosin has a much higher ATPase rate than in the other. Shifting myosin into the state with the higher ATPase activity in resting muscle will increase the metabolic rate of the muscle, leading to treatments for obesity and Type 2 diabetes.

The Cooke Lab uses biophysical, biochemical and physiological techniques. We specialize in:

  • Electron paramagnetic resonance and fluorescence spectroscopy
  • Single skeletal muscle fiber mechanics
  • Studies of the mechanism of thermogenesis in skeletal muscle
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