Nuclear Architecture and Chromosome Organization
Our research is aimed at understanding the organization of chromosomes within the nucleus, the detailed architecture of the chromosomes themselves, and the functional roles this organization plays in determining chromosome behavior.
In order to carry out these studies we have developed several new methods of three-dimensional microscopy, including computerized wide-field deconvolution microscopy for multiwavelength fluorescence imaging of living cells, and electron tomography for three-dimensional imaging in the elctron microscope.
Learn More: Images of Nuclei and ChromosomesMapping the Interactions of Chromatin with Nuclear Envelope
Drosophila Polytene Chromosomes
Chromosome Dynamics During Mitosis in Drosophila (movie)
Chromatin Brownian Motion (movie)
Visualization of Mitochondrial Growth and Transmission in Yeast Using GFP (movie)