Recent and Selected

Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96Å. Franz Gruswitz, Joseph O'Connell, III, and Robert M. Stroud. (2007) PNAS 104; 42-47.
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The Role of Protein Dynamics in Thymidylate Synthase Catalysis: Variants of Conserved 2'-Deoxyuridine 5'-Monophosphate (dUMP)-Binding Tyr-261. Zachary Newby, Tom T. Lee, Richard J. Morse, Yaoquan Liu, Lu Liu, Prasanna Venkatraman,
Daniel V. Santi, Janet S. Finer-Moore, and Robert M. Stroud. (2006) Biochemistry Vol 45, 24.
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Substrate Recognition by RNA 5-Methyluridine Methyltransferases and Pseudouridine Synthases: A Structural Perspective. Sun Hur, Robert M. Stroud, and Janet Finer-Moore. (2006) The Journal of Biological Chemistry Vol. 281, No. 51, pp. 38969–38973.
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The Structure of a Ketoreductase Determines the Organization of the b-Carbon Processing Enzymes of Modular Polyketide Synthases. Adrian T. Keatinge-Clay, and Robert M. Stroud. (2006) Structure 14, 737–748.
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Gas Channels for Ammonia. Khademi, S., and Stroud,R.M. (2006), Invited Chapter in Royal Society of Chemistry: Structural Biology of Membrane Proteins, ed., Reinhard Grisshammer and Susan K. Buchanan. Chapter 12, 212-234.

The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction. Khademi, S., and Stroud, R.M. (2006) Physiology (Bethesda)21: 419-429.

Aquaporins: Integral Membrane Channel Proteins. Stroud, R.M., Harries, W.E.C., Lee, J, Khademi, S., and Savage, D (2006), Invited Chapter  in Royal Society of Chemistry: Structural Biology of Membrane Proteins, ed., Reinhard Grisshammer and Susan K. Buchanan. Chapter 11, 195-211.

On the Mechanism of Sensing Unfolded Protein in the Endoplasmic Reticulum.Credle, J.J., Finer-Moore, J.S., Papa, F.R., Stroud, R.M. and Walter, P. (2005) Proc Nat Acad Sci  102, 18773-18784

Structural Basis for Conductance by the Archaeal Aquaporin AqpM at 1.68Å. Lee, J.K., Stroud, R.M.  (2005) Proc. Nat Acad Sci U S A 102, 18932-7.

A unique RNA fold in the rumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Lee, T., Agarwalla, S., Stroud, R.M. (2005) Cell 120, 599-611.
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Targeting proteins to membranes: structure of the signal recognition particle. Egea, P.F., Stroud, R.M., Walter, P. (2005) Current Opinion in Structural Biology 15:213-220.
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De novo design of an IL-4 antagonist and its structure at 1.9Å. LaPorte, S.L., Forsyth, C.M., Cunningham, B.C., Miercke, L.J., Akhaven, D., Stroud, R.M. (2004) PNAS vol 102 no.6 1889-1894.
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Mechanism of association and reciprocal activation of two GTPases. Shan, S. O., Stroud, R. M., Walter, P. (2004) PLoS Biol 2, e320
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Structure of Human Pro-Chymase: A Model for the Activating Transition of Granule Associated Proteases. Reiling, K.K Krucinski, J. Miercke,L.J.W. Raymond, W.W., Caughey, G.H. Stroud, R.M. (2003) Biochemistry 42, 2616-2624. PDB accession No. 1NN6
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Conformational Dynamics Along an Enzymatic Reaction Pathway: Thymidylate Synthase, ‘the Movie.’ Robert M. Stroud, Janet S. Finer-Moore (2003) Biochemistry 42, 239-247. (web released Dec 17th 2002 Bi 020598i)
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Anisotropic Dynamics of the JE-2147-HIV Protease complex: Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09Å Structure. Reiling, K., Endres, N., Dauber, D., Craik, C., Stroud, R. (2002) Biochemistry 41 No 14 4582 –4594.
PDB accession No. 1KZK
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Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthases: Versatility from a unique substrate channel. Tsai, S.-C., Miercke, L.J.W., Krucinski, J., Gokhale, R., Chen, Julian C.-H., Foster, P.G., Cane, D.E., Khosla, C., and Stroud, R.M. (2001). PNAS 98 26 14808-14813.
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Crystal Structure of the HIV-1 Integrase Catalytic Core and C-Terminal Domains Presents a Model for Viral DNA Binding. Chen, J. C.-H., Krucinski, J., Miercke, L.J.W., Finer-Moore, J.S., Tang, A.H., Leavitt, A.D., and Stroud, R.M. (2000) Proc. of Natl. Acad. Sci. 97, 15 8233-8238.
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Functional consequences of the Kaposi's Sarcoma-associated herpesviral protease structure: Regulation of activity and dimerization by conserved structural elements. Reiling, K.K., Pray, T.R., Craik, C.S., and Stroud, R.M. (2000) Biochemistry 39, 42 12796-803.
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Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+ GDP.
Freyman, DM; Keenan, RJ; Stroud, RM; and Walter, P. (1999) Nature Structural Biology 6, 793-801. PDB Accession Nos. 1NG1, 2NG1 , 3NG1
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