Isocitrate Dehydrogenase

Active site water molecules revealed in the 2.1 Å resolution structure of a site-directed mutant of isocitrate dehydrogenase.
Cherbavaz, DB; Lee, ME; Stroud, RM; and Koshland, DE, Jr. (2000)
J. Mol. Biol. 295, 377-385.
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Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Finer-Moore, J; Tsutakawa, SE; Cherbavaz, DB; LaPorte, DC; Koshland, DE Jr; and Stroud, RM. (1997)
Biochemistry 36, 13890-13896.
PDB Accession No. 1SJS
Review abstract
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Subscribers may view article in Biochemistry Web Edition 1997
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Mechanisms of biological control by phosphorylation.
Stroud, RM. (1991)
Current Opinion in Structural Biology 1, 826-835.

Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Hurley, JH; Dean, AM; Koshland, DE Jr; Stroud, RM. (1991)
Biochemistry 30, 8671-8678.
PDB Accession No. 9ICD
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Regulation of an enzyme by phosphorylation at the active site.
Hurley, JH; Dean, AM; Sohl, JL; Koshland, DE Jr; Stroud, RM. (1990)
Science 249, 1012-1016.
PDB Accession Nos. 5ICD, 6ICD, 7ICD & 8ICD
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Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
Hurley, JH; Dean, AM; Thorsness, PE; Koshland, DE Jr; Stroud, RM. (1990)
Journal of Biological Chemistry 265, 3599-3602.
PDB Accession No. 4ICD
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Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Hurley, JH; Thorsness, PE; Ramalingam, V; Helmers, NH;  Koshland, DE; and Stroud, RM. (1989)
Proceedings of the National Academy of Sciences (USA) 86, 8635-9.
PDB Accession No. 3ICD
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