Figure 1

Inhibitors designed to bind active site region.

Figure 2: N-terminus(1-50)

a. Dimeric 3-helical bundle
b. Conserved HHCC Zn binding motif
c. DNA recognition multimeric assembly (Cai et al, 1997, 1998)

Figure 3: Core (51-212)

a. Alpha-beta fold(2.5§)
b. 3 conserved catalytic residues (D64, D116, E152)
c. Flexible active site loop (140-149)
d. Dimer with active sites 35§ apart (Dyda e al, 1994; Jenkins 1995)

Figure 3: C-terminus (213-288)

SH3-like 5-stranded beta barrel stabilizes DNA binding (R263. K264) multimeric assembly. (Eijkelenboom 1995, Lodi 1995)