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Construct
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Vector Log |
Signal Recognition Particle
| Homologues of SRP54, SRP RNA, and the a
subunit of the SRP receptor have been identified and isolated
in E. coli and other bacteria. In E. coli, the homologues Ffh,
4.5S RNA, and FtsY, respectively, have been shown to function
in a parallel pathway to eukaryote SRP. The 37 kD 4.5S RNA
and the 47 kD Ffh form a complex that interacts with the 33
kD receptor FtsY in a manner that reciprocally stimulates the
GTPase activity of both the Ffh and FtsY. The 4.5S RNA although
much smaller than the eukaryote SRP RNA, stabilizes the interaction
between these enzymes.
PDB Structure Downloads |
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Freymann, DM; Keenan, RJ; Stroud, RM; Walter, P. Nature 385, 361-64, January
23, 1997. |
Figure 2 |
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 Figure from "Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+ GDP."
Freyman, DM; Keenan, RJ; Stroud, RM; and Walter, P. (1999) |